Chest pain, trouble breathing or severe bleeding?Life-threatening emergency? Call 911.
Urgent careHours listed · see hours

Express Care

1008 N Main St, Sikeston, MO 63801

1.01 review

Nearby urgent care

All urgent care in Sikeston

Hours

  • Mon8 AMto7 PM
  • Tue8 AMto7 PM
  • Wed8 AMto7 PM
  • Thu8 AMto7 PM
  • Fri8 AMto7 PM
  • Sat8 AMto4 PM
  • Sun8 AMto4 PM

Hours can change on holidays; call to confirm.

Insurance

1 insurance network lists this location.

  • Aetna3 plans
Plan names listed (3)
Aetna
  • Aetna Health Inc. - Georgia
  • Aetna Health Inc. - New Jersey
  • Aetna Health Inc. - PA

Call to confirm your plan. Networks change and the clinic has the final word.

About Express Care

Express Care is an urgent care center at 1008 N Main St, Sikeston, MO 63801. It is about 0.9 miles from the center of Sikeston, and the nearest other city we list is Matthews, 9.0 miles away. Its listed hours: open weekdays 8 AM to 7 PM and weekends 8 AM to 4 PM. It is listed with 1 insurance network: Aetna. It has 1 published review on this site, averaging 1.0 out of 5.

At a glance

Care level
Urgent care
Open 24 hours
No
Days open
7 days a week
Insurance networks listed
1
To the center of Sikeston
0.9 mi

If it’s an emergency

Call 911 for chest pain, trouble breathing, signs of a stroke, severe bleeding or a serious injury. Urgent care centers are not emergency rooms.

Call 911

What urgent care centers usually treat

General information, not medical advice. Services vary; call Express Care to ask what it offers.

  • Fever and flu
  • Cuts and stitches
  • Sprains and X-rays
  • Sore throat and strep
  • Urinary tract infections
  • Rashes and allergic reactions
  • Ear infections
  • Vaccines and physicals
  • COVID and flu tests
  • Work and DOT physicals

Before you go

General checklist.

  • A photo ID
  • Your insurance card, if you have one
  • A list of your medicines and allergies
  • A way to pay a copay or the visit
  • Call (573) 472-6001 to confirm today’s hours and that your plan is accepted
  • Most urgent care centers take walk-ins, and some also offer online check-in; ask when you call

Cost at a glance

Typical US ranges, not quotes. Ask Express Care for its prices when you call.

  • Urgent care visit, billed before insurance$229–$445
  • Urgent care copay with insurance$25–$75
  • Emergency room visit, self-pay$1,200–$2,500+

Reviews

1.01 published review of Express Care
  • Anonymous
    July 28, 2026
    1 out of 5

    Terrible experience, in reference to the nurse practitioner acting like a physician. Moody was his last name. On Saturday Went in for brown recluse bite on my arm. Expecting to get some type of treatment ie. steroids antibiotics. He claimed it barely bit me and I need to let it run its course. Told him I didn't want a big hole in my arm. Dr. Claimed it wouldn't happen. Went to my physician Monday, cause it was worse. She wanted to know why I hadn't gotten treatment sooner. She instantly gave me a shot, steroids and antibiotic. All I have now is a rotting black hole under my arm and a bill. He was uncaring and unprofessional.

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Other urgent care centers in Sikeston

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Questions

Express Care is located at 1008 N Main St, Sikeston, MO 63801.

Nearby cities

The information on this page is general information, not medical advice. Please verify hours, insurance and services directly with Express Care before visiting. In a medical emergency, call 911.